Advair (Salmeterol / Fluticasone)

Advair Review

Advair Diskus is used for long-term prevention and treatment of asthma and chronic lung diseases

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Advair Drug Class and Mechanism

Since ADVAIR DISKUS contains both fluticasone propionate and salmeterol, the mechanisms of action described below for the individual components apply to ADVAIR DISKUS. These drugs represent 2 classes of medications (a synthetic corticosteroid and a selective, long-acting beta-adrenergic receptor agonist) that have different effects on clinical and physiological indices.

Advair Uses

The combination preparation fluticasone/salmeterol is a formulation containing fluticasone propionate and salmeterol xinafoate used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is marketed by GlaxoSmithKline under various trade names including Advair (USA), Seretide (EU), Viani (Germany), Adoair (Japan), and ForAir (India). Fluticasone, a corticosteroid, is the anti-inflammatory component of the combination, while salmeterol treats constriction of the airways. Together, they relieve the symptoms of coughing, wheezing and shortness of breath better than either fluticasone or salmeterol taken on its own. The recommended regimen for asthma in individuals 12 years and older is one inhalation twice daily (morning and evening) approximately 12 hours apart. The lowest effective strength should be used and the maximum dose is 500/50 mcg twice daily. For children 4 to 11 years old the recommended treatment is one inhalation of 100/50 mcg twice daily.

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Advair Side Effects

The common and minor side effects of this combination are those of its individual drugs. For instance, the use of inhaled corticosteroids is associated with oral candidiasis. Whilst the use of inhaled steroids and long acting beta-adrenoceptor agonist (LABA) are recommended in asthma guidelines for the resulting improved symptom control, concerns have been raised that salmeterol may increase the small risks of asthma deaths and this additional risk is not reduced with the additional use of inhaled steroids.This seems to occur because although LABAs relieve asthma symptoms, they also promote bronchial inflammation and sensitivity without warning.

Advair Pregnancy

Advair Overdose

No deaths occurred in rats given an inhaled single-dose combination of salmeterol 3.6 mg/kg (approximately 290 and 140 times, respectively, the maximum recommended daily inhalation dose in adults and children on a mg/m2 basis) and 1.9 mg/kg of fluticasone propionate (approximately 15 and 35 times, respectively, the maximum recommended daily inhalation dose in adults and children on a mg/m2 basis).

Advair More Information

Advair Discus is to be used only by the patient for whom it is prescribed. Do not share it with other people